Ref. Description   Package
AKO0801 Anti n-DNA 50 test
Identification of anti-n-DNA antibodies associated with Systemic Lupus Erythematosus (LES, SLE). Serum agglutination test.


The immune system in SLE pathogenesis. The abnormal degradation of apoptotic material and the components of the NET (extracellular trap of neutrophils) are recognized by antibodies and immunocomprehends circulating with pCDs stimulation (dendritic cell plasmacitoids), DCs (dendritic cell) myeloid, basophilic, neutrophils, macrophages / monocytes, with the final release of pro-inflammatory cytokines such as IL-4, IL-6, IL-1b, IL-18, TNF-a, type I IFN and BAFF. The activation of B and T cells leads to the amplification of antibody production and chronic inflammation.






HMGB1               High-Motility Box-1 Proteins

HNP                      Peptide Neutrophil Human

MPO                     Mieloperoxidas

BAFF                    Cells B Activation Factor

TLR                      Transport Receptors

IC                         immune complex

NRLP3                  NOD Pyrinic Receptor

IL                            Interleuchin

IFN                        Interferon

TNF                       tumor necrosis factor